Scientist role HTS (non-PhD) | Pfizer Jobs at California, United States

Scientist role HTS (non-PhD) | Pfizer Jobs at California, United States

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development are at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy, or supporting clinical trials, you will apply cutting-edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

As a Scientist, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be part of a team that is addressing the critical task of rejuvenating our pipeline with innovative, differentiated First-In-Class/ Only-In-Class programs in the years to come. This will be addressed by the generation of strong data packages from target hypotheses derived from academic outreach and initiatives. You will be an essential member of this team and creatively design and execute key experiments to address the basic and translational biology of novel drug targets, their molecular pathways, and their connection to human disease. With your deep knowledge in the discipline, you will be an active team member who influences at the project team level. You will be using your scientific judgment to adopt standard methods and techniques by applying prior work experience and consulting others. Your ability to plan will help in preparing short-term work activities on projects. Your creativity in developing novel processes and new ideas will be used frequently.

The Pfizer Oncology Research Unit in La Jolla is seeking a full-time employee to support the drug discovery process for innovative medicines to treat cancer.  We are seeking a BS/MS level cell biologist with experience performing cell based high throughput screens (HTS).  The candidate should have knowledge in the field of drug discovery, cancer signaling, method development, and scientific technologies.  The candidate should also have skills and expertise in tissue culture, various assay technologies, assay development, automation and instrumentation, and data analysis.  This is an exciting opportunity to combine research and technology in order to help Pfizer discover breakthrough medicines that change patients’ lives.

How You Will Achieve It

  • Independently execute HTS campaigns while using various specialized robotic systems and data management software packages.
  • Successfully perform scientific assays to evaluate various cellular processes such as cell proliferation, protein degradation, transcription/translation, signal transduction, cellular biomarkers, cell migration, apoptosis, cell cycle regulation, etc.
  • Optimize/Miniaturize existing assays as well as develop new assays for HTS.
  • Grow, maintain, and scale up >10 cancer cell lines simultaneously in order to generate cell reagents for downstream assays.
  • Critically QC and analyze results and summarize his/her findings to project teams or in department meetings.
  • Effectively communicate and collaborate with other functions and teams such as sample logistics, other biology groups, and chemistry.
  • Help maintain and program laboratory instruments to facilitate multiple successful HTS campaigns throughout the year; Help evaluate, acquire, and implement new instruments, when needed.
  • Record experiments and results into laboratory notebooks.



  • A B.S or M.S. in biochemistry, biology, bioengineering, chemistry, or other related field with 6+ years in an industrial or academic pharmaceutical laboratory setting.
  • 6+ years of cell biology/tissue culture experience and a minimum of 3+ years in a HTS environment.
  • Excellent aseptic techniques and organization to perform tissue culture of >10 cell lines simultaneously without cross contamination.
  • Knowledge in various scientific and assay technologies and platforms such as but not limited to:  HiBiT, ePL, NanoBRET, Luminescence, Fluorescence, HTRF, ELISA, MSD, flow cytometer, western blotting, cell staining and imaging.
  • Knowledge in HTS and drug dose response curve fitting statistics and data visualization; Familiarity with several of the following software packages:  Activity Base, XLFit, MathIQ, Biobook, Prism, Genedata Screener, Dotmatics, Spotfire, Vortex, Seurat, Pipleline Pilot, D360.
  • Proficiency in using and programming laboratory automation and instruments such as but not limited to:  traditional liquid handlers, fluorescence/luminescence based plate readers, phenotypic cell imagers, flow cytometers, acoustic dispensers, digital printers, bulk reagent dispensers, plate washers, hand held pipettors, etc.
  • Strong organization skills with an emphasis on attention to detail in order to enable multitasking and scheduling of multiple experiments/projects.
  • Knowledge of the general small molecule drug discovery process from Hit ID to optimization and to candidate selection.
  • Strong work ethic, self-motivation, fast learner, independent but team oriented, strong communication skills, and an ability to work with a broad range of personalities.
  • Strong computer and software skills to include but not limited to being highly proficient with Microsoft Office.


  • Wet lab experience running both biochemical/biophysical AND cell-based assays.
  • Experience with both traditional 2D cancer cell culture AND 3D culture models.
  • Additional knowledge of molecular, biochemical, and biophysical techniques such as molecular cloning, lentivirus, siRNA, CRISPR, SPR, DSF/TSA, CETSA.
  • Knowledge of combination analysis and synergy is a plus.
  • Experience acquiring and implementing new laboratory equipment and platforms.
  • Knowledge of compound registration, sample management, sample requesting, and other related processes.
  • Computer programming knowledge is a plus.

Physical/Mental Requirements

  • Candidate will be required to operate various laboratory instruments and hand-held pipettors, lift and transport large stacks of plates, and will need to walk between labs to get to various instruments and supply centers regularly. 
  • Candidate will also be performing tissue culture duties which may require spending several hours sitting in front of a biological safety cabinet. 
  • Candidate may need to use step stools to climb and reach items above eye level. 
  • Candidate will also diagnose and repair equipment with various tools occasionally. 
  • Must be able to work safely in a laboratory environment with lab coat, protective eye wear and gloves.
  • The job can require standing and walking for most of the day regularly.

Non-Standard Work Schedule, Environment Requirements

  • Generally speaking, a standard work schedule is required in order to perform lab responsibilities and to attend various meetings throughout the week.
  • However, in light of the current pandemic and the desire to minimize close contact, staggered work shifts have been implemented for the current times.
  • Currently, shifts are either morning/afternoon or afternoon/evening.

Other Job Details

  • Eligible for Employee Referral Bonus
  • #LI-PFE

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations.  These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure.  Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.  Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.  If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Pfizer is an E-Verify employer.

Research and Development

Click here to apply.

Rajat Singh
Rajat Singh is the chief Author at Bioinformatics India, he has been writing for the past 3 years and has a special interest in SEO, Technology, Health, Life Sciences and gaming.

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