Neurons are being designed to live longer

    Neurons are being designed to live longer

    We do as our neurons die — the brain ‘s key cells.

    During embryonic development, most neurons are formed and have no “backup” after birth. Researchers also typically assumed that their longevity is either directly determined or by external factors, including nerves delivering nerve cells to tissues and organs.

    This notion has been questioned by a research team led by Sika Zheng, a biomedical scientist in Riverside, University of California, and reports that the continued survival of neurons is also intrinsic to growth.

    The study published in Neuron demonstrates a mechanism by which the researchers conclude that at neuron birth a general process of cell death — or “apoptosis”—especially in the neurons has been activated.

    After stopping this genetic manipulation, continuous neuronal survival is disrupted and the animal is killed.

    The longevity of an organism, its brain activity, and its fitness depends on its neuronal survival. Within superior bodies, nourishment, feeling, action, memory, emotion and awareness are regulated by neurons.

    Some artificial causes, such as neurodegenerative disorders, illness, cancer and trauma will kill them. Neurons are long-lived cells, but the genetic controls that enable their longevity are unknown.

    The core part of the process involved is now identified by Zheng ‘s team as a small genetic sequence in Bak1, a pro-apoptotic gene whose activation leads to apoptosis. The expression bak1 is turned off when the final Bak1 gene product breaks this short gene sequence known when microexone. Exons are sequences which constitute the RNA messenger.

    “Apoptosis is a mechanism for regulating cell turnover and homeostasis of the tissue in a metazoan,” said Zheng, a biomedical sciences associate professor.

    “Most nonneural cells undergo readily apoptosis in response to innate and extrinsic stress. However, this suicide neuronal system must be re-infected with neurons so that they are alive for a period of years.

    A broad review of data on expression from human tissues, mouse tissues, human brain growth, forebrain forming of the mouse and the growth of midbrains identified the Bak1 microphone by Zheng ‘s team. The first team to classify neural exons matches neuronal tissues with non-neural tissues in both humans and mice.

    Then cortical neurons reduced their apoptosis susceptibility as long as they were synaptic. They have also observed that apoptosis is gradually reduced in neuronal growth before neurons bind or interact with other cells.

    “We teach neurons how cell death during development is controlled,” Zheng said. “It is designed to ensure the synaptic survival required for the stability of brain functional neural circuits.”

    Next, the Zheng team will research whether the pathway found is triggered in neuro-degenerative and neuronal cell mortality injuries.

    Neurons are being designed to live longer

    Rajat Singh
    Rajat Singh is the Editor-in-chief at Bioinformatics India, he is a Master's in Bioinformatics and validates all the data present on this website. Independent of his academic qualifications he is a marketing geek and loves to explore trends in SEO, Keyword research, Web design & UI/UX improvement.

    Get in Touch

    Related Articles

    Get in Touch


    Latest Posts